| Gene Information | |
|---|---|
| Gene Name | ATG5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 275 |
| Protein Names | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000057663 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H1Y0 |
| Gene Card | ATG5 |
| Uniprot ID | Q9H1Y0 |
| Pfam | PF04106 |
| In ASD | no |
| Allosteric Prediction | yes (0.300449173) |
| Ortholog in Animals | Alpaca_ ATG5 ( ortholog_one2one ) Dog_ ATG5 ( ortholog_one2one ) GuineaPig_ ATG5 ( ortholog_one2one ) Macaque_ ATG5 ( ortholog_one2one ) Mouse_ Atg5 ( ortholog_one2one ) Pig_ ATG5 ( ortholog_one2one ) Rat_ Atg5 ( ortholog_one2one ) Rabbit_ ATG5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. |
| Pharmacological Animal Models | 0.020968(Chimpanzee);0.020650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4GDK (X-ray 2.70A ) 4GDL (X-ray 2.88A ) 4NAW (X-ray 2.20A ) 4TQ0 (X-ray 2.70A ) 4TQ1 (X-ray 1.80A ) 5D7G (X-ray 3.00A ) 5NPV (X-ray 3.10A ) 5NPW (X-ray 3.10A ) |
| DBSNP | rs1131692265 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17709747}. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |