| Gene Information | |
|---|---|
| Gene Name | ATG4D |
| Organism | Homo sapiens (Human) |
| Gene Length | 474 |
| Protein Names | Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 4) (Autophagin-4) (Autophagy-related protein 4 homolog D) (HsAPG4D) [Cleaved into: Cysteine protease ATG4D, mitochondrial] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000130734 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86TL0 |
| Gene Card | ATG4D |
| Uniprot ID | Q86TL0 |
| Pfam | PF03416 |
| In ASD | no |
| Allosteric Prediction | no (-0.350528929) |
| Ortholog in Animals | Alpaca_ ATG4D ( ortholog_one2one ) Dog_ ATG4D ( ortholog_one2one ) GuineaPig_ ATG4D ( ortholog_one2one ) Macaque_ ATG4D ( ortholog_one2one ) Mouse_ Atg4d ( ortholog_one2one ) Pig_ ATG4D ( ortholog_one2one ) Rat_ Atg4d ( ortholog_one2one ) Rabbit_ ATG4D ( ortholog_one2one ) |
| Ohnologs | ATG4C |
| Paralogs | ATG4C, ATG4B, ATG4A |
| Tissue | NA |
| Tissue Specificity | Widely expressed in testis. {ECO:0000269|PubMed:33988247}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1216040637 rs145807760 rs1261979779 rs201291151 |
| Subcellular location [CC] | [Cysteine protease ATG4D]: Cytoplasm {ECO:0000269|PubMed:19549685}.; [Cysteine protease ATG4D, mitochondrial]: Cytoplasm {ECO:0000269|PubMed:19549685}. Mitochondrion matrix {ECO:0000269|PubMed:19549685, ECO:0000269|PubMed:22441018}. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. {ECO:0000269|PubMed:22441018}. |
| Mouse PG classification | NA |
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