| Gene Information | |
|---|---|
| Gene Name | FARP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1045 |
| Protein Names | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000152767 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9Y4F1 |
| Gene Card | FARP1 |
| Uniprot ID | Q9Y4F1 |
| Pfam | PF08736; PF09380; PF00373; PF09379; PF00169; PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-0.834101343) |
| Ortholog in Animals | Alpaca_ FARP1 ( ortholog_one2one ) Dog_ FARP1 ( ortholog_one2one ) GuineaPig_ FARP1 ( ortholog_one2one ) Macaque_ FARP1 ( ortholog_one2one ) Mouse_ Farp1 ( ortholog_one2one ) Pig_ FARP1 ( ortholog_one2one ) Rat_ Farp1 ( ortholog_one2one ) Rabbit_ FARP1 ( ortholog_one2one ) |
| Ohnologs | FRMD7, FARP2 |
| Paralogs | ECT2L, ARHGEF39, FGD5, FARP2, FGD6, FGD4, FGD3, FGD2, FRMD7, FGD1 |
| Tissue | NA |
| Tissue Specificity | Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. {ECO:0000269|PubMed:9425278}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4H6Y (X-ray 4.09A ) |
| DBSNP | rs9300466 rs1458028855 |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Synapse, synaptosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}. |
| Mouse PG classification | NA |
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