| Gene Information | |
|---|---|
| Gene Name | PVRIG |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) |
| Target Name | transmembrane protein pvrig |
| Target Type | Clinical trial target |
| Gene Age | 70 ( ENSG00000213413 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q6DKI7 |
| Gene Card | PVRIG |
| Uniprot ID | Q6DKI7 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.159432426) |
| Ortholog in Animals | Alpaca_ PVRIG ( ortholog_one2one ) Dog_ PVRIG ( ortholog_one2one ) GuineaPig_ PVRIG ( ortholog_one2one ) Macaque_ PVRIG ( ortholog_one2one ) Mouse_ Pvrig ( ortholog_one2one ) Pig_ PVRIG ( ortholog_one2one ) Rat_ AABR07035561.2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells. {ECO:0000269|PubMed:26755705}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2906645 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26755705}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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