| Gene Information | |
|---|---|
| Gene Name | ACVR2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) |
| Target Name | activin receptor type iia |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000121989 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P27037 |
| Gene Card | ACVR2A |
| Uniprot ID | P27037 |
| Pfam | PF01064; PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.541916656) |
| Ortholog in Animals | Alpaca_ ACVR2A ( ortholog_one2one ) Dog_ ACVR2A ( ortholog_one2one ) GuineaPig_ ACVR2A ( ortholog_one2one ) Macaque_ ACVR2A ( ortholog_one2one ) Mouse_ Acvr2a ( ortholog_one2one ) Pig_ ACVR2A ( ortholog_one2one ) Rat_ Acvr2a ( ortholog_one2one ) Rabbit_ ACVR2A ( ortholog_one2one ) |
| Ohnologs | ACVR2B, TGFBR2 |
| Paralogs | ACVR1, BMPR2, TGFBR2, ACVR2B, TGFBR1, BMPR1A, AMHR2, ACVR1B, BMPR1B, ACVRL1, ACVR1C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);0.094737(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3Q4T (X-ray 1.96A ) 3SOC (X-ray 1.95A ) 4ASX (X-ray 2.05A ) 5NH3 (X-ray 2.35A ) 7U5P (X-ray 3.14A ) |
| DBSNP | rs34917571 rs764255410 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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