| Gene Information | |
|---|---|
| Gene Name | PRUNE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 453 |
| Protein Names | Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000143363 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86TP1 |
| Gene Card | PRUNE1 |
| Uniprot ID | Q86TP1 |
| Pfam | PF01368; PF02833 |
| In ASD | no |
| Allosteric Prediction | no (-0.467031281) |
| Ortholog in Animals | Alpaca_ PRUNE1 ( ortholog_one2one ) Dog_ PRUNE1 ( ortholog_one2one ) GuineaPig_ PRUNE1 ( ortholog_one2one ) Macaque_ PRUNE1 ( ortholog_one2one ) Mouse_ Prune1 ( ortholog_one2one ) Pig_ PRUNE1 ( ortholog_one2one ) Rat_ Prune1 ( ortholog_one2one ) Rabbit_ PRUNE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:15671547}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1057521927 rs1085308033 rs773618224 rs767769359 rs752599948 rs3738477 rs3738477 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed. |
| Mouse PG classification | NA |
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