| Gene Information | |
|---|---|
| Gene Name | ATF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 351 |
| Protein Names | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) |
| Target Name | activator protein 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000128272 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P18848 |
| Gene Card | ATF4 |
| Uniprot ID | P18848 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | yes (0.189705619) |
| Ortholog in Animals | Alpaca_ ATF4 ( ortholog_one2one ) Dog_ ATF4 ( ortholog_one2one ) GuineaPig_ ATF4 ( ortholog_one2one ) Macaque_ ATF4 ( ortholog_one2one ) Mouse_ Atf4 ( ortholog_one2one ) Pig_ ATF4 ( ortholog_one2one ) Rat_ Atf4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATF5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CI6 (X-ray 2.60A ) |
| DBSNP | rs4894 rs1803323 rs1803324 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:22974638, ECO:0000269|PubMed:23123191, ECO:0000269|PubMed:31444471}. Nucleus speckle {ECO:0000269|PubMed:16219772}. Cytoplasm {ECO:0000250|UniProtKB:Q9ES19}. Cell membrane {ECO:0000250|UniProtKB:Q9ES19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). {ECO:0000250|UniProtKB:Q9ES19, ECO:0000269|PubMed:16219772, ECO:0000269|PubMed:20873783}. |
| Mouse PG classification | NA |
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