| Gene Information | |
|---|---|
| Gene Name | AZU1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 251 |
| Protein Names | Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP) (hHBP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000172232 ) 3 ( ENSG00000278624 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20160 |
| Gene Card | AZU1 |
| Uniprot ID | P20160 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.346479442) |
| Ortholog in Animals | Alpaca_ AZU1 ( ortholog_one2one ) Macaque_ AZU1 ( ortholog_one2one ) Pig_ AZU1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KLK13, KLK6, GZMB, GZMH, CMA1, CTSG |
| Tissue | bone.marrow, left.ventricle, spleen, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A7S (X-ray 1.12A ) 1AE5 (X-ray 2.30A ) 1FY1 (X-ray 2.50A ) 1FY3 (X-ray 1.89A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic granule membrane {ECO:0000269|PubMed:2312733, ECO:0000269|PubMed:2501794}; Peripheral membrane protein {ECO:0000269|PubMed:2312733}; Cytoplasmic side {ECO:0000269|PubMed:2312733}. Note=Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. {ECO:0000269|PubMed:2312733, ECO:0000269|PubMed:2501794}. |
| Mouse PG classification | NA |
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