| Gene Information | |
|---|---|
| Gene Name | MYO7A |
| Organism | Homo sapiens (Human) |
| Gene Length | 2215 |
| Protein Names | Unconventional myosin-VIIa |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000137474 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13402 |
| Gene Card | MYO7A |
| Uniprot ID | Q13402 |
| Pfam | PF00373; PF00612; PF00063; PF00784 |
| In ASD | no |
| Allosteric Prediction | no (-0.775913173) |
| Ortholog in Animals | Alpaca_ MYO7A ( ortholog_one2one ) Dog_ MYO7A ( ortholog_one2one ) GuineaPig_ MYO7A ( ortholog_one2one ) Macaque_ MYO7A ( ortholog_one2one ) Mouse_ Myo7a ( ortholog_one2one ) Pig_ MYO7A ( ortholog_one2one ) Rat_ Myo7a ( ortholog_one2one ) Rabbit_ MYO7A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYH7, MYO1A, MYO15A, MYH9, MYO18A, MYO1E, MYH14, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYH7B, MYO5B, CGNL1, CGN, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13 |
| Tissue | adrenal.gland, placenta, spleen, testis, pituitary.gland |
| Tissue Specificity | Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain. {ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:21493626, ECO:0000269|PubMed:21709241}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5MV9 (X-ray 2.60A ) |
| DBSNP | rs1052030 rs782252317 rs369125667 rs1555054747 rs111033403 rs111033181 rs1555062409 rs1472566324 rs111033174 rs1188616455 rs781946292 rs121965080 rs28934610 rs111033283 rs782166819 rs121965081 rs781896482 rs41298135 rs1555067667 rs1269622956 rs111033286 rs121965084 rs111033206 rs121965082 rs2276282 rs876657416 rs35641839 rs782174733 rs368341987 rs1296612982 rs781988557 rs111033233 rs375050157 rs111033214 rs111033178 rs749747871 rs373169422 rs763469001 rs1437625274 rs41298747 rs139889944 rs2276288 rs77625410 rs12275336 rs111033287 rs377267777 rs368657015 rs397516321 rs111033215 rs199606180 rs948962 rs771906493 rs1191025888 rs1132036 rs747656448 rs397516332 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P97479}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P97479}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P97479}. Synapse {ECO:0000269|PubMed:8842737}. Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region (PubMed:8842737). In retinal pigment epithelial cells colocalizes with a subset of melanosomes, displays predominant localization to stress fiber-like structures and some localization to cytoplasmic puncta (PubMed:19643958, PubMed:27331610). Detected at the tip of cochlear hair cell stereocilia (PubMed:21709241). The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin (PubMed:21709241). {ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:21709241, ECO:0000269|PubMed:27331610, ECO:0000269|PubMed:8842737}. |
| Mouse PG classification | HPG |
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