| Gene Information | |
|---|---|
| Gene Name | ASXL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1541 |
| Protein Names | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000171456 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IXJ9 |
| Gene Card | ASXL1 |
| Uniprot ID | Q8IXJ9 |
| Pfam | PF13919; PF05066; PF13922 |
| In ASD | no |
| Allosteric Prediction | yes (0.085942549) |
| Ortholog in Animals | Alpaca_ ASXL1 ( ortholog_one2one ) Dog_ ASXL1 ( ortholog_one2one ) GuineaPig_ ASXL1 ( ortholog_one2one ) Macaque_ ASXL1 ( ortholog_one2one ) Mouse_ Asxl1 ( ortholog_one2one ) Pig_ ASXL1 ( ortholog_one2one ) Rat_ Asxl1 ( ortholog_one2one ) Rabbit_ ASXL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ASXL3, ASXL2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes. {ECO:0000269|PubMed:10231032, ECO:0000269|PubMed:12657473}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6058693 rs6058694 rs34359205 rs6057581 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
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