| Gene Information | |
|---|---|
| Gene Name | ASTL |
| Organism | Homo sapiens (Human) |
| Gene Length | 431 |
| Protein Names | Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000188886 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6HA08 |
| Gene Card | ASTL |
| Uniprot ID | Q6HA08 |
| Pfam | PF01400 |
| In ASD | no |
| Allosteric Prediction | no (-0.92186159) |
| Ortholog in Animals | Alpaca_ ASTL ( ortholog_one2one ) Dog_ ASTL ( ortholog_one2one ) GuineaPig_ ASTL ( ortholog_one2one ) Macaque_ ASTL ( ortholog_one2one ) Mouse_ Astl ( ortholog_one2one ) Pig_ ASTL ( ortholog_one2one ) Rat_ Astl ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7ST8 (X-ray 2.75A ) |
| DBSNP | rs41320144 rs749458 rs1657502 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q6HA09}. Cell membrane {ECO:0000250|UniProtKB:Q6HA09}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q6HA09}. Note=Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages. Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS). {ECO:0000250|UniProtKB:Q6HA09}. |
| Mouse PG classification | NA |
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