Gene Information
Gene NameUMOD
OrganismHomo sapiens (Human)
Gene Length640
Protein NamesUromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000169344 )
Evolutionary StageEumetazoa
AlphaFoldDBP07911
Gene CardUMOD
Uniprot IDP07911
PfamPF12947; PF07645; PF00100
In ASDno
Allosteric Predictionno (-0.999602197)
Ortholog in AnimalsAlpaca_ UMOD ( ortholog_one2one )
Dog_ UMOD ( ortholog_one2one )
GuineaPig_ UMOD ( ortholog_one2one )
Macaque_ UMOD ( ortholog_one2one )
Mouse_ Umod ( ortholog_one2one )
Pig_ UMOD ( ortholog_one2one )
Rat_ Umod ( ortholog_one2one )
Rabbit_ UMOD ( ortholog_one2one )
OhnologsNA
ParalogsGP2, ZPLD1, TECTB, OIT3, UMODL1
Tissuekidney, cortex.of.kidney
Tissue SpecificityExpressed in the tubular cells of the kidney. Most abundant protein in normal urine (at protein level). Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen. {ECO:0000269|PubMed:18375198, ECO:0000269|PubMed:22776760, ECO:0000269|PubMed:23988501, ECO:0000269|PubMed:3453112, ECO:0000269|PubMed:7028707}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4WRN  (X-ray  3.20A  )  6TQK  (EM  3.35A  )  6TQL  (EM  3.96A  )  6ZS5  (EM  3.50A  )  6ZYA  (EM  3.50A  )  7PFP  (EM  6.10A  )  7Q3N  (EM  7.40A  ) 
DBSNP rs121917768  rs28934584  rs780462125  rs1555487621  rs121917769  rs121917770  rs28934582  rs28934583  rs28934583  rs1447458978  rs886043751  rs121917771  rs121917772  rs121917773  rs1555487318  rs55772253 
Subcellular location [CC]Apical cell membrane {ECO:0000269|PubMed:22776760, ECO:0000269|PubMed:23988501, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:7028707};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2249987}. Basolateral cell membrane {ECO:0000269|PubMed:7028707};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2249987}. Cell projection, cilium membrane {ECO:0000269|PubMed:20172860}. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization (PubMed:22776760). Secreted into urine after cleavage (PubMed:18375198, PubMed:26811476). Colocalizes with NPHP1 and KIF3A (PubMed:20172860). {ECO:0000269|PubMed:18375198, ECO:0000269|PubMed:20172860, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:3453112, ECO:0000269|PubMed:7028707}.;
[Uromodulin, secreted form]: Secreted {ECO:0000269|PubMed:18375198, ECO:0000269|PubMed:19005207, ECO:0000269|PubMed:26673890, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:3453112, ECO:0000269|PubMed:7028707}. Note=Detected in urine. {ECO:0000269|PubMed:18375198, ECO:0000269|PubMed:26811476, ECO:0000269|PubMed:3453112, ECO:0000269|PubMed:7028707}.
Mouse PG classificationHPG
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