Gene Information
Gene NameASRGL1
OrganismHomo sapiens (Human)
Gene Length308
Protein NamesIsoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]
Target Nameasparaginase
Target TypeSuccessful target
Gene Age886 ( ENSG00000162174 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ7L266
Gene CardASRGL1
Uniprot IDQ7L266
PfamPF01112
In ASDno
Allosteric Predictionyes (0.223839042)
Ortholog in AnimalsAlpaca_ ASRGL1 ( ortholog_one2one )
Dog_ SCGB1A1 ( ortholog_one2one )
GuineaPig_ ASRGL1 ( ortholog_one2one )
Macaque_ ASRGL1 ( ortholog_one2one )
Mouse_ Asrgl1 ( ortholog_one2one )
Pig_ ASRGL1 ( ortholog_one2one )
Rat_ Asrgl1 ( ortholog_one2one )
Rabbit_ ASRGL1 ( ortholog_one2one )
OhnologsTASP1
ParalogsAGA, TASP1
TissueNA
Tissue SpecificityExpressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:14654938}.
Pharmacological Animal Models0.050380(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3TKJ  (X-ray  2.30A  )  4ET0  (X-ray  3.30A  )  4O0C  (X-ray  1.50A  )  4O0D  (X-ray  1.95A  )  4O0E  (X-ray  1.71A  )  4O0F  (X-ray  1.92A  )  4O0G  (X-ray  2.10A  )  4O0H  (X-ray  1.97A  )  4OSX  (X-ray  1.95A  )  4OSY  (X-ray  1.91A  )  4PVP  (X-ray  1.85A  )  4PVQ  (X-ray  2.13A  )  4PVR  (X-ray  1.75A  )  4PVS  (X-ray  1.84A  )  4ZM9  (X-ray  2.51A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:27106100}. Note=Midpiece of sperm tail.
Mouse PG classificationNA
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