| Gene Information | |
|---|---|
| Gene Name | ASPN |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Asporin (Periodontal ligament-associated protein 1) (PLAP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000106819 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BXN1 |
| Gene Card | ASPN |
| Uniprot ID | Q9BXN1 |
| Pfam | PF13855; PF01462 |
| In ASD | no |
| Allosteric Prediction | no (-0.987315929) |
| Ortholog in Animals | Alpaca_ ASPN ( ortholog_one2one ) Dog_ ASPN ( ortholog_one2one ) GuineaPig_ ASPN ( ortholog_one2one ) Macaque_ ASPN ( ortholog_one2one ) Mouse_ Aspn ( ortholog_one2one ) Pig_ ASPN ( ortholog_one2one ) Rat_ Aspn ( ortholog_one2one ) Rabbit_ ASPN ( ortholog_one2one ) |
| Ohnologs | LUM |
| Paralogs | LRTM1, LRRTM3, BGN, LRRTM1, LRRC19, RTN4RL2, LRRC4B, NYX, PODN, LRRC15, FLRT2, FLRT1, LRRTM4, LRRC66, RTN4RL1, LRRC4, PODNL1, FLRT3, DCN, GP1BA, RTN4R, LRRC4C |
| Tissue | mitral.valve |
| Tissue Specificity | Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung. Colocalizes with TGFB1 in chondrocytes within osteoarthritic (OA) lesions of articular cartilage. {ECO:0000269|PubMed:17827158}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17827158}. |
| Mouse PG classification | NA |
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