| Gene Information | |
|---|---|
| Gene Name | ASPM |
| Organism | Homo sapiens (Human) |
| Gene Length | 3477 |
| Protein Names | Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000066279 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | ASPM |
| Uniprot ID | Q8IZT6 |
| Pfam | PF15780; PF00307; PF00612 |
| In ASD | no |
| Allosteric Prediction | no (-0.196262774) |
| Ortholog in Animals | Alpaca_ ASPM ( ortholog_one2one ) Dog_ ASPM ( ortholog_one2one ) Macaque_ ASPM ( ortholog_one2one ) Mouse_ Aspm ( ortholog_one2one ) Pig_ ASPM ( ortholog_one2one ) Rat_ Aspm ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MICALL2, EHBP1L1, SMTNL1, EHBP1, MICALL1, GAS2L1, GAS2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.052632(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12025066 rs6428388 rs7551108 rs16841081 rs964201 rs587783267 rs41310927 rs12138336 rs3762271 rs36004306 rs193251130 rs7528827 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15972725}. Nucleus {ECO:0000250}. Note=The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule minus ends (By similarity). {ECO:0000250|UniProtKB:Q8CJ27}. |
| Mouse PG classification | HPG |
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