| Gene Information | |
|---|---|
| Gene Name | FAM107A |
| Organism | Homo sapiens (Human) |
| Gene Length | 144 |
| Protein Names | Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000168309 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95990 |
| Gene Card | FAM107A |
| Uniprot ID | O95990 |
| Pfam | PF06625 |
| In ASD | no |
| Allosteric Prediction | no (-1.450281189) |
| Ortholog in Animals | Alpaca_ FAM107A ( ortholog_one2one ) Dog_ FAM107A ( ortholog_one2one ) GuineaPig_ FAM107A ( ortholog_one2one ) Macaque_ FAM107A ( ortholog_one2one ) Mouse_ Fam107a ( ortholog_one2one ) Rat_ Fam107a ( ortholog_one2one ) Rabbit_ FAM107A ( ortholog_one2one ) |
| Ohnologs | FAM107B |
| Paralogs | FAM107B |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:10564580). Expressed in neurons (PubMed:20543869). Expressed in malignant glial tumors (PubMed:20543869). Expression is reduced or absent in a number of cancer cell lines (PubMed:10564580). {ECO:0000269|PubMed:10564580, ECO:0000269|PubMed:20543869}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1043942 rs11539086 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10564580, ECO:0000269|PubMed:11256614, ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. Cell junction, focal adhesion {ECO:0000269|PubMed:20543869}. Cell projection, ruffle membrane {ECO:0000269|PubMed:20543869}. Synapse {ECO:0000250|UniProtKB:Q78TU8}. Note=Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869). {ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. |
| Mouse PG classification | NA |
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