| Gene Information | |
|---|---|
| Gene Name | RTCB |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) |
| Target Name | trna-splicing ligase rtcb homolog |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000100220 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9Y3I0 |
| Gene Card | RTCB |
| Uniprot ID | Q9Y3I0 |
| Pfam | PF01139 |
| In ASD | no |
| Allosteric Prediction | no (-0.423457096) |
| Ortholog in Animals | Alpaca_ RTCB ( ortholog_one2one ) Macaque_ RTCB ( ortholog_one2one ) Mouse_ Rtcb ( ortholog_one2one ) Pig_ RTCB ( ortholog_one2one ) Rat_ Rtcb ( ortholog_one2many ) Rat_ AABR07057196.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.020421(Chimpanzee);0.051209(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7P3B (X-ray 2.30A ) |
| DBSNP | rs11545747 rs17849275 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24608264}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03144, ECO:0000269|PubMed:24608264}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000269|PubMed:24608264}. |
| Mouse PG classification | NA |
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