| Gene Information | |
|---|---|
| Gene Name | ATP6AP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000182220 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75787 |
| Gene Card | ATP6AP2 |
| Uniprot ID | O75787 |
| Pfam | PF07850 |
| In ASD | no |
| Allosteric Prediction | no (-0.030656506) |
| Ortholog in Animals | Alpaca_ ATP6AP2 ( ortholog_one2one ) Dog_ ATP6AP2 ( ortholog_one2one ) GuineaPig_ ATP6AP2 ( ortholog_one2one ) Macaque_ ATP6AP2 ( ortholog_one2one ) Mouse_ Atp6ap2 ( ortholog_one2one ) Pig_ ATP6AP2 ( ortholog_one2one ) Rat_ Atp6ap2 ( ortholog_one2one ) Rabbit_ ATP6AP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta. {ECO:0000269|PubMed:12045255, ECO:0000269|PubMed:15746149}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3LBS (X-ray 2.15A ) 3LC8 (X-ray 2.00A ) 6WLW (EM 3.00A ) 6WM2 (EM 3.10A ) 6WM3 (EM 3.40A ) 6WM4 (EM 3.60A ) 7U4T (EM 3.60A ) |
| DBSNP | rs1057523485 rs9014 rs35798522 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:29127204}; Single-pass type I membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:29127204}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CYN9}. Endosome membrane {ECO:0000250|UniProtKB:Q9CYN9}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q6AXS4}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6AXS4}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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