| Gene Information | |
|---|---|
| Gene Name | ASIC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 531 |
| Protein Names | Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1) |
| Target Name | acid-sensing ion channel 3 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000213199 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UHC3 |
| Gene Card | ASIC3 |
| Uniprot ID | Q9UHC3 |
| Pfam | PF00858 |
| In ASD | yes |
| Allosteric Prediction | yes (0.99963084) |
| Ortholog in Animals | Alpaca_ ASIC3 ( ortholog_one2one ) Dog_ ASIC3 ( ortholog_one2one ) GuineaPig_ ASIC3 ( ortholog_one2one ) Macaque_ ASIC3 ( ortholog_one2one ) Mouse_ Asic3 ( ortholog_one2one ) Pig_ ASIC3 ( ortholog_one2one ) Rat_ Asic3 ( ortholog_one2one ) Rabbit_ ASIC3 ( ortholog_one2one ) |
| Ohnologs | ASIC1, ASIC4, SCNN1D |
| Paralogs | ASIC1, ASIC5, SCNN1B, SCNN1G, ASIC4, SCNN1A, SCNN1D, ASIC2 |
| Tissue | putamen |
| Tissue Specificity | Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. {ECO:0000269|PubMed:9571199, ECO:0000269|PubMed:9886053}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1864545 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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