| Gene Information | |
|---|---|
| Gene Name | TREML2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 321 |
| Protein Names | Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000112195 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q5T2D2 |
| Gene Card | TREML2 |
| Uniprot ID | Q5T2D2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.427766909) |
| Ortholog in Animals | Alpaca_ TREML2 ( ortholog_one2one ) Dog_ TREML2 ( ortholog_one2one ) Macaque_ TREML2 ( ortholog_one2one ) Mouse_ Treml2 ( ortholog_one2one ) Rat_ Treml2 ( ortholog_one2one ) Rabbit_ TREML2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NCR2, TREML4 |
| Tissue | whole.blood |
| Tissue Specificity | Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4418164 rs35512890 rs3747742 rs35521209 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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