| Gene Information | |
|---|---|
| Gene Name | ASIC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 512 |
| Protein Names | Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG) |
| Target Name | acid-sensing ion channel 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000108684 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16515 |
| Gene Card | ASIC2 |
| Uniprot ID | Q16515 |
| Pfam | PF00858 |
| In ASD | no |
| Allosteric Prediction | yes (0.578027093) |
| Ortholog in Animals | Alpaca_ ASIC2 ( ortholog_one2one ) Dog_ ASIC2 ( ortholog_one2one ) GuineaPig_ ASIC2 ( ortholog_one2one ) Macaque_ ASIC2 ( ortholog_one2one ) Mouse_ Asic2 ( ortholog_one2one ) Pig_ ASIC2 ( ortholog_one2one ) Rat_ Asic2 ( ortholog_one2one ) Rabbit_ ASIC2 ( ortholog_one2one ) |
| Ohnologs | ASIC4, ASIC1, SCNN1B |
| Paralogs | ASIC1, ASIC5, SCNN1B, SCNN1G, ASIC4, SCNN1A, SCNN1D, ASIC3 |
| Tissue | brain, endometrium |
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:8631835}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6L6P (X-ray 3.08A ) |
| DBSNP | rs16967895 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250}. |
| Mouse PG classification | NA |
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