| Gene Information | |
|---|---|
| Gene Name | ASGR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 291 |
| Protein Names | Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1) |
| Target Name | asialoglycoprotein receptor 1 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000141505 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P07306 |
| Gene Card | ASGR1 |
| Uniprot ID | P07306 |
| Pfam | PF00059 |
| In ASD | no |
| Allosteric Prediction | no (-0.23933048) |
| Ortholog in Animals | Alpaca_ ASGR1 ( ortholog_one2one ) Dog_ CLEC10A ( ortholog_one2one ) GuineaPig_ ASGR1 ( ortholog_one2one ) Macaque_ ASGR1 ( ortholog_one2one ) Mouse_ Asgr1 ( ortholog_one2one ) Pig_ ASGR1 ( ortholog_one2one ) Rat_ Asgr1 ( ortholog_one2one ) Rabbit_ ASGR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CLEC4G, CLEC4C, CLEC4M, CLEC17A, ASGR2, CLEC4A, CLEC4F, CLEC10A, CLEC6A, FCER2, CD209, CLEC4D, CD207, CLEC4E |
| Tissue | liver |
| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DV8 (X-ray 2.30A ) 5JPV (X-ray 1.90A ) 5JQ1 (X-ray 1.83A ) 6YAU (X-ray 1.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform H1a]: Membrane; Single-pass type II membrane protein.; [Isoform H1b]: Secreted {ECO:0000269|PubMed:20886072}. |
| Mouse PG classification | NA |
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