| Gene Information | |
|---|---|
| Gene Name | LIMA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 759 |
| Protein Names | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000050405 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UHB6 |
| Gene Card | LIMA1 |
| Uniprot ID | Q9UHB6 |
| Pfam | PF00412 |
| In ASD | no |
| Allosteric Prediction | no (-0.043645324) |
| Ortholog in Animals | Alpaca_ LIMA1 ( ortholog_one2one ) Dog_ LIMA1 ( ortholog_one2one ) GuineaPig_ LIMA1 ( ortholog_one2one ) Macaque_ CERS5 ( ortholog_one2one ) Mouse_ Lima1 ( ortholog_one2one ) Pig_ LIMA1 ( ortholog_one2one ) Rat_ Lima1 ( ortholog_one2one ) Rabbit_ LIMA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium. {ECO:0000269|PubMed:24694988}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2D8Y (NMR - ) |
| DBSNP | rs140372565 |
| Subcellular location [CC] | Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:10618726, ECO:0000269|PubMed:24694988}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:10618726}. Cell membrane {ECO:0000250|UniProtKB:Q9ERG0}. Note=Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:24694988, ECO:0000269|PubMed:29880681}. |
| Mouse PG classification | NA |
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