| Gene Information | |
|---|---|
| Gene Name | ASB10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | Ankyrin repeat and SOCS box protein 10 (ASB-10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146926 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8WXI3 |
| Gene Card | ASB10 |
| Uniprot ID | Q8WXI3 |
| Pfam | PF12796; PF07525 |
| In ASD | no |
| Allosteric Prediction | no (-0.93642941) |
| Ortholog in Animals | Alpaca_ ASB10 ( ortholog_one2many ) Dog_ ASB10 ( ortholog_one2one ) GuineaPig_ ASB10 ( ortholog_one2one ) Macaque_ ASB10 ( ortholog_one2one ) Mouse_ Asb10 ( ortholog_one2one ) Pig_ ASB10 ( ortholog_one2one ) Rat_ Asb10 ( ortholog_one2one ) Rabbit_ ASB10 ( ortholog_one2one ) |
| Ohnologs | ASB16, ASB18 |
| Paralogs | ASB18, ASB15, MPHOSPH8, ASB16, ASB3, ASB4, ASB14 |
| Tissue | skeletal.muscle |
| Tissue Specificity | Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens. {ECO:0000269|PubMed:22156576}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs151344615 rs104886491 rs151344616 rs104886488 rs151344617 rs104886490 rs147737381 rs151344619 rs151344604 rs151344605 rs104886473 rs151344607 rs104886474 rs61735708 rs140602973 rs151344609 rs61735130 rs151344610 rs104886481 rs104886482 rs151344611 rs151344612 rs62489646 rs919533 rs104886487 rs3800791 rs104886462 rs104886465 rs104886467 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22156576}. Nucleus {ECO:0000269|PubMed:22156576}. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells. |
| Mouse PG classification | NA |
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