| Gene Information | |
|---|---|
| Gene Name | GCSAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 178 |
| Protein Names | Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000174500 ) 3 ( ENSG00000284925 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8N6F7 |
| Gene Card | GCSAM |
| Uniprot ID | Q8N6F7 |
| Pfam | PF15666 |
| In ASD | no |
| Allosteric Prediction | no (-0.888779475) |
| Ortholog in Animals | Alpaca_ GCSAM ( ortholog_one2one ) Dog_ GCSAM ( ortholog_one2one ) GuineaPig_ GCSAM ( ortholog_one2one ) Macaque_ GCSAM ( ortholog_one2one ) Mouse_ Gcsam ( ortholog_one2one ) Pig_ GCSAM ( ortholog_one2one ) Rat_ Gcsam ( ortholog_one2one ) Rabbit_ GCSAM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GCSAML |
| Tissue | lymph.node, tonsil, appendix |
| Tissue Specificity | Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. {ECO:0000269|PubMed:12509382, ECO:0000269|PubMed:12819018, ECO:0000269|PubMed:15677569}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6. |
| Mouse PG classification | NA |
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