Gene Information
Gene NameASAH2
OrganismHomo sapiens (Human)
Gene Length780
Protein NamesNeutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form]
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000188611 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9NR71
Gene CardASAH2
Uniprot IDQ9NR71
PfamPF04734; PF17048
In ASDno
Allosteric Predictionno (-0.824810091)
Ortholog in AnimalsAlpaca_ ASAH2 ( ortholog_one2one )
Dog_ ASAH2 ( ortholog_one2one )
GuineaPig_ ASAH2 ( ortholog_one2one )
Macaque_ ASAH2 ( ortholog_one2one )
Mouse_ Asah2 ( ortholog_one2one )
Pig_ ASAH2 ( ortholog_one2one )
Rat_ Asah2 ( ortholog_one2one )
Rabbit_ ASAH2 ( ortholog_one2one )
OhnologsNA
ParalogsASAH2B
Tissueduodenum, small.intestine
Tissue SpecificityPrimarily expressed in intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). The ubiquitous expression observed for ASAH2 might be an experimental artifact due to the paralog ASAH2B (PubMed:17334805). {ECO:0000269|PubMed:10781606, ECO:0000269|PubMed:17334805}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4WGK  (X-ray  2.58A  ) 
DBSNP rs7067625  rs1052952953 
Subcellular location [CC][Neutral ceramidase]: Cell membrane {ECO:0000269|PubMed:15845354};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane raft {ECO:0000250|UniProtKB:Q9JHE3};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Membrane, caveola {ECO:0000250|UniProtKB:Q9JHE3};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Golgi apparatus membrane {ECO:0000269|PubMed:30154232};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q91XT9}. Mitochondrion {ECO:0000269|PubMed:10781606}. Secreted, extracellular exosome {ECO:0000269|PubMed:24798654}. Note=Enriched in exosomes upon stimulation by cytokine (PubMed:24798654). Enriched in caveolae and lipid rafts (By similarity). The localization to the mitochondrion could not be confirmed (PubMed:15845354). {ECO:0000250|UniProtKB:Q9JHE3, ECO:0000269|PubMed:15845354, ECO:0000269|PubMed:24798654}.;
[Neutral ceramidase soluble form]: Secreted {ECO:0000250|UniProtKB:Q91XT9}.
Mouse PG classificationNA
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