| Gene Information | |
|---|---|
| Gene Name | ARX |
| Organism | Homo sapiens (Human) |
| Gene Length | 562 |
| Protein Names | Homeobox protein ARX (Aristaless-related homeobox) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000004848 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96QS3 |
| Gene Card | ARX |
| Uniprot ID | Q96QS3 |
| Pfam | PF00046; PF03826 |
| In ASD | no |
| Allosteric Prediction | no (-0.51084237) |
| Ortholog in Animals | Alpaca_ ARX ( ortholog_one2one ) Dog_ ARX ( ortholog_one2one ) GuineaPig_ ARX ( ortholog_one2one ) Macaque_ ARX ( ortholog_one2one ) Mouse_ Arx ( ortholog_one2one ) Pig_ ARX ( ortholog_one2one ) Rat_ Arx ( ortholog_one2one ) Rabbit_ ARX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | ovary |
| Tissue Specificity | Expressed predominantly in fetal and adult brain and skeletal muscle. Expression is specific to the telencephalon and ventral thalamus. There is an absence of expression in the cerebellum throughout development and also in adult. {ECO:0000269|PubMed:11889467, ECO:0000269|PubMed:11971879, ECO:0000269|PubMed:12359145}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.085714(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs28936077 rs28935479 rs111033612 rs104894745 rs104894741 rs104894743 rs746120093 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}. |
| Mouse PG classification | LPG |
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