| Gene Information | |
|---|---|
| Gene Name | ARSG |
| Organism | Homo sapiens (Human) |
| Gene Length | 525 |
| Protein Names | Arylsulfatase G (ASG) (EC 3.1.6.1) (N-sulfoglucosamine-3-sulfatase) (EC 3.1.6.15) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000141337 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96EG1 |
| Gene Card | ARSG |
| Uniprot ID | Q96EG1 |
| Pfam | PF00884 |
| In ASD | no |
| Allosteric Prediction | no (-0.494839177) |
| Ortholog in Animals | Alpaca_ ARSG ( ortholog_one2one ) Dog_ ARSG ( ortholog_one2one ) GuineaPig_ ARSG ( ortholog_one2one ) Macaque_ ARSG ( ortholog_one2one ) Mouse_ Arsg ( ortholog_one2one ) Pig_ ARSG ( ortholog_one2one ) Rat_ Arsg ( ortholog_one2one ) Rabbit_ ARSG ( ortholog_one2one ) |
| Ohnologs | ARSD, ARSF, STS, ARSL, ARSH |
| Paralogs | IDS, ARSA, ARSL, SULF1, STS, ARSI, ARSH, SGSH, GALNS, SULF2, GNS, ARSB, ARSJ, ARSF, ARSD, ARSK |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with very low expression in brain, lung, heart and skeletal muscle. {ECO:0000269|PubMed:12461688, ECO:0000269|PubMed:18283100, ECO:0000269|PubMed:29300381}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs8074806 rs1558876 rs1558878 rs144503106 rs9972951 rs11657051 rs62000424 rs370852507 rs61999318 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:12461688, ECO:0000269|PubMed:18283100}. Note=The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. {ECO:0000250|UniProtKB:Q3TYD4}. |
| Mouse PG classification | NA |
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