| Gene Information | |
|---|---|
| Gene Name | TMEM43 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Transmembrane protein 43 (Protein LUMA) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000170876 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BTV4 |
| Gene Card | TMEM43 |
| Uniprot ID | Q9BTV4 |
| Pfam | PF07787 |
| In ASD | no |
| Allosteric Prediction | no (-0.899300438) |
| Ortholog in Animals | Alpaca_ TMEM43 ( ortholog_one2one ) Dog_ TMEM43 ( ortholog_one2one ) GuineaPig_ TMEM43 ( ortholog_one2one ) Macaque_ TMEM43 ( ortholog_one2one ) Mouse_ Tmem43 ( ortholog_one2one ) Pig_ TMEM43 ( ortholog_one2one ) Rat_ Tmem43 ( ortholog_one2one ) Rabbit_ TMEM43 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis. {ECO:0000269|PubMed:18230648}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs397514044 rs144811578 rs4685076 rs2340917 rs35924492 rs11924644 rs63750743 rs773224617 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:32614325}. Nucleus inner membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:34050020}. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |