| Gene Information | |
|---|---|
| Gene Name | ARRDC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 414 |
| Protein Names | Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000113369 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96B67 |
| Gene Card | ARRDC3 |
| Uniprot ID | Q96B67 |
| Pfam | PF02752; PF00339 |
| In ASD | no |
| Allosteric Prediction | no (-0.598041639) |
| Ortholog in Animals | Alpaca_ ARRDC3 ( ortholog_one2one ) Dog_ ARRDC3 ( ortholog_one2one ) GuineaPig_ ARRDC3 ( ortholog_one2one ) Macaque_ ARRDC3 ( ortholog_one2one ) Mouse_ Arrdc3 ( ortholog_one2one ) Pig_ ARRDC3 ( ortholog_one2one ) Rat_ Arrdc3 ( ortholog_one2one ) Rabbit_ ARRDC3 ( ortholog_one2one ) |
| Ohnologs | ARRDC2, ARRDC4 |
| Paralogs | ARRDC1, ARRDC4, ARRDC5, ARRDC2, TXNIP |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow (PubMed:16269462). Strong expression in differentiated adipocytes compared to preadipocytes (PubMed:16269462). Detected in omental fat and subcutaneous fat tissue (PubMed:21982743). {ECO:0000269|PubMed:16269462}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001990(Rat);0.044444(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4N7H (X-ray 1.70A ) 4R7V (X-ray 1.73A ) 4R7X (X-ray 2.61A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Cell membrane {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}; Peripheral membrane protein {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325}; Cytoplasmic side {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325}. Lysosome {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Endosome {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:23208550}. Early endosome {ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325). {ECO:0000269|PubMed:16269462, ECO:0000269|PubMed:20559325, ECO:0000269|PubMed:23208550}. |
| Mouse PG classification | NA |
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