| Gene Information | |
|---|---|
| Gene Name | ARRB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 409 |
| Protein Names | Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000141480 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P32121 |
| Gene Card | ARRB2 |
| Uniprot ID | P32121 |
| Pfam | PF02752; PF00339 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999735483) |
| Ortholog in Animals | Alpaca_ ARRB2 ( ortholog_one2one ) Dog_ ARRB2 ( ortholog_one2one ) GuineaPig_ ARRB2 ( ortholog_one2one ) Macaque_ ARRB2 ( ortholog_one2one ) Mouse_ Arrb2 ( ortholog_one2one ) Pig_ ARRB2 ( ortholog_one2one ) Rat_ Arrb2 ( ortholog_one2one ) |
| Ohnologs | ARR3, ARRB1 |
| Paralogs | ARRB1, ARR3, SAG |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. |
| Mouse PG classification | NA |
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