| Gene Information | |
|---|---|
| Gene Name | ARRB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000137486 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P49407 |
| Gene Card | ARRB1 |
| Uniprot ID | P49407 |
| Pfam | PF02752; PF00339 |
| In ASD | no |
| Allosteric Prediction | yes (0.724962475) |
| Ortholog in Animals | Alpaca_ ARRB1 ( ortholog_one2one ) Dog_ ARRB1 ( ortholog_one2one ) GuineaPig_ ARRB1 ( ortholog_one2one ) Macaque_ ARRB1 ( ortholog_one2one ) Mouse_ Arrb1 ( ortholog_one2one ) Pig_ ARRB1 ( ortholog_one2one ) Rat_ Arrb1 ( ortholog_one2many ) Rabbit_ ARRB1 ( ortholog_one2one ) |
| Ohnologs | ARR3, ARRB2 |
| Paralogs | ARRB2, ARR3, SAG |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.017391(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IV8 (X-ray 2.80A ) 6PWC (EM 4.90A ) 6TKO (EM 3.30A ) 6UP7 (EM 4.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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