| Gene Information | |
|---|---|
| Gene Name | RUFY3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 469 |
| Protein Names | Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000018189 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7L099 |
| Gene Card | RUFY3 |
| Uniprot ID | Q7L099 |
| Pfam | PF02759 |
| In ASD | no |
| Allosteric Prediction | no (-1.048815191) |
| Ortholog in Animals | Alpaca_ RUFY3 ( ortholog_one2one ) Dog_ RUFY3 ( ortholog_one2one ) GuineaPig_ RUFY3 ( ortholog_one2one ) Mouse_ Rufy3 ( ortholog_one2one ) Pig_ RUFY3 ( ortholog_one2one ) Rat_ Rufy3 ( ortholog_one2one ) Rabbit_ RUFY3 ( ortholog_one2one ) |
| Ohnologs | RUFY1, RUFY2 |
| Paralogs | RUFY1, PLEKHF1, ZFYVE1, ZFYVE26, ZFYVE28, RUNDC3B, RUFY2, PLEKHM2, RUNDC3A, ZFYVE16, PLEKHF2, SNX29, ZFYVE19 |
| Tissue | NA |
| Tissue Specificity | Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321). {ECO:0000269|PubMed:25766321}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:25766321}. Endomembrane system {ECO:0000269|PubMed:20376209}. Cell projection, invadopodium {ECO:0000269|PubMed:25766321}. Perikaryon {ECO:0000250|UniProtKB:Q9D394}. Cell projection {ECO:0000250|UniProtKB:Q9D394}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D394}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9D394}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9D394}. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalized with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalized with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalized with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:20376209, ECO:0000269|PubMed:25766321}. |
| Mouse PG classification | NA |
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