Gene Information | |
---|---|
Gene Name | ARNO |
Organism | Homo sapiens (Human) |
Gene Length | 400 |
Protein Names | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) |
Target Name | NA |
Target Type | NA |
Gene Age | NA |
Evolutionary Stage | NA |
AlphaFoldDB | Q99418 |
Gene Card | CYTH2 |
Uniprot ID | Q99418 |
Pfam | PF00169; PF01369 |
In ASD | no |
Allosteric Prediction | NA |
Ortholog in Animals | NA |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | Widely expressed. {ECO:0000305|PubMed:9417041}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 1PBV (X-ray 2.00A ) 1R8M (X-ray 1.70A ) 1R8Q (X-ray 1.86A ) 1R8S (X-ray 1.46A ) 1S9D (X-ray 1.80A ) 4JMI (X-ray 1.50A ) 4JMO (X-ray 1.80A ) 4JWL (X-ray 1.95A ) 4JXH (X-ray 1.47A ) 4L5M (X-ray 1.80A ) 4Z21 (X-ray 2.05A ) |
DBSNP | NA |
Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm {ECO:0000269|PubMed:17398095}. Cell projection {ECO:0000250|UniProtKB:P63034}. Cell projection, growth cone {ECO:0000250|UniProtKB:P63034}. Cell junction, tight junction {ECO:0000250|UniProtKB:P63034}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P63034}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas. {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}. |
Mouse PG classification | NA |
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