| Gene Information | |
|---|---|
| Gene Name | FOLR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 255 |
| Protein Names | Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP) |
| Target Name | folate receptor beta |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000165457 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P14207 |
| Gene Card | FOLR2 |
| Uniprot ID | P14207 |
| Pfam | PF03024 |
| In ASD | no |
| Allosteric Prediction | no (-0.326235325) |
| Ortholog in Animals | Alpaca_ FOLR2 ( ortholog_one2one ) Macaque_ FOLR2 ( ortholog_one2one ) Mouse_ Folr2 ( ortholog_one2many ) Rat_ Folr2 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | FOLR3, FOLR1, IZUMO1R, RTBDN |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4KMY (X-ray 1.80A ) 4KMZ (X-ray 2.30A ) 4KN0 (X-ray 2.10A ) 4KN1 (X-ray 2.30A ) 4KN2 (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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