| Gene Information | |
|---|---|
| Gene Name | ALYREF |
| Organism | Homo sapiens (Human) |
| Gene Length | 257 |
| Protein Names | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000183684 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86V81 |
| Gene Card | ALYREF |
| Uniprot ID | Q86V81 |
| Pfam | PF13865; PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-1.169352893) |
| Ortholog in Animals | Alpaca_ ALYREF ( ortholog_one2one ) Dog_ ALYREF ( ortholog_one2one ) GuineaPig_ ALYREF ( ortholog_one2one ) Macaque_ ALYREF ( ortholog_one2one ) Mouse_ Gm4307 ( ortholog_one2many ) Mouse_ Alyref2 ( ortholog_one2many ) Mouse_ Gm8764 ( ortholog_one2many ) Mouse_ Gm6489 ( ortholog_one2many ) Mouse_ Alyref ( ortholog_one2many ) Mouse_ Gm21312 ( ortholog_one2many ) Mouse_ Gm4312 ( ortholog_one2many ) Mouse_ Gm4302 ( ortholog_one2many ) Mouse_ Gm4308 ( ortholog_one2many ) Mouse_ Gm20765 ( ortholog_one2many ) Mouse_ Gm21304 ( ortholog_one2many ) Mouse_ Gm4303 ( ortholog_one2many ) Mouse_ Gm4340 ( ortholog_one2many ) Mouse_ Gm21293 ( ortholog_one2many ) Mouse_ Gm4301 ( ortholog_one2many ) Mouse_ Gm4305 ( ortholog_one2many ) Mouse_ 4931428L18Rik ( ortholog_one2many ) Mouse_ Gm6763 ( ortholog_one2many ) Mouse_ Gm5698 ( ortholog_one2many ) Pig_ ALYREF ( ortholog_one2one ) Rat_ Alyref ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | POLDIP3, CHTOP |
| Tissue | NA |
| Tissue Specificity | Expressed in a wide variety of cancer types. {ECO:0000269|PubMed:25662211}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ULH (X-ray 2.54A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10488337, ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332, ECO:0000269|PubMed:28418038, ECO:0000305|PubMed:18974867}. Nucleus speckle {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Cytoplasm {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:28418038}. Note=Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:19324961). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. |
| Mouse PG classification | NA |
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