| Gene Information | |
|---|---|
| Gene Name | ARL2BP |
| Organism | Homo sapiens (Human) |
| Gene Length | 163 |
| Protein Names | ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (ARL2-binding protein) (Binder of ARF2 protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000102931 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y2Y0 |
| Gene Card | ARL2BP |
| Uniprot ID | Q9Y2Y0 |
| Pfam | PF11527 |
| In ASD | no |
| Allosteric Prediction | no (-0.864002531) |
| Ortholog in Animals | Alpaca_ ARL2BP ( ortholog_one2one ) Macaque_ ARL2BP ( ortholog_one2one ) Mouse_ Arl2bp ( ortholog_one2one ) Pig_ ARL2BP ( ortholog_one2one ) Rat_ Arl2bp ( ortholog_one2many ) Rabbit_ ARL2BP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in retina pigment epithelial cells (at protein level). Widely expressed. {ECO:0000269|PubMed:10488091, ECO:0000269|PubMed:23849777}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K9A (NMR - ) 3DOE (X-ray 2.25A ) 3DOF (X-ray 3.30A ) |
| DBSNP | rs398123053 rs7198865 |
| Subcellular location [CC] | Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization. {ECO:0000250}. |
| Mouse PG classification | NA |
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