| Gene Information | |
|---|---|
| Gene Name | RNF182 |
| Organism | Homo sapiens (Human) |
| Gene Length | 247 |
| Protein Names | E3 ubiquitin-protein ligase RNF182 (EC 2.3.2.27) (RING finger protein 182) (RING-type E3 ubiquitin transferase RNF182) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000180537 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8N6D2 |
| Gene Card | RNF182 |
| Uniprot ID | Q8N6D2 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.844342474) |
| Ortholog in Animals | Alpaca_ RNF182 ( ortholog_one2one ) Dog_ RNF182 ( ortholog_one2one ) GuineaPig_ RNF182 ( ortholog_one2one ) Macaque_ RNF182 ( ortholog_one2one ) Mouse_ Rnf182 ( ortholog_one2one ) Pig_ RNF182 ( ortholog_one2one ) Rat_ Rnf182 ( ortholog_one2one ) Rabbit_ RNF182 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RC3H1, RNF227, RC3H2, RNF224 |
| Tissue | brain |
| Tissue Specificity | Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains (PubMed:18298843). Highly expressed in innate immune organs such as lymph nodes and spleen and in immune cells such as macrophages and dendritic cells (PubMed:31432514). {ECO:0000269|PubMed:18298843, ECO:0000269|PubMed:31432514}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18298843, ECO:0000269|PubMed:31432514}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |