| Gene Information | |
|---|---|
| Gene Name | MEK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 393 |
| Protein Names | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q02750 |
| Gene Card | MAP2K1 |
| Uniprot ID | Q02750 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with extremely low levels in brain. {ECO:0000269|PubMed:1281467}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001190(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1S9J (X-ray 2.40A ) 2P55 (X-ray 2.80A ) 3DV3 (X-ray 2.30A ) 3DY7 (X-ray 2.70A ) 3E8N (X-ray 2.50A ) 3EQB (X-ray 2.62A ) 3EQC (X-ray 1.80A ) 3EQD (X-ray 2.10A ) 3EQF (X-ray 2.70A ) 3EQG (X-ray 2.50A ) 3EQH (X-ray 2.00A ) 3EQI (X-ray 1.90A ) 3MBL (X-ray 2.60A ) 3ORN (X-ray 2.80A ) 3OS3 (X-ray 2.80A ) 3PP1 (X-ray 2.70A ) 3SLS (X-ray 2.30A ) 3V01 (X-ray 2.70A ) 3V04 (X-ray 2.70A ) 3VVH (X-ray 2.00A ) 3W8Q (X-ray 2.20A ) 3WIG (X-ray 2.70A ) 3ZLS (X-ray 2.50A ) 3ZLW (X-ray 2.12A ) 3ZLX (X-ray 2.20A ) 3ZLY (X-ray 2.11A ) 3ZM4 (X-ray 2.37A ) 4AN2 (X-ray 2.50A ) 4AN3 (X-ray 2.10A ) 4AN9 (X-ray 2.80A ) 4ANB (X-ray 2.20A ) 4ARK (X-ray 2.60A ) 4LMN (X-ray 2.80A ) 4MNE (X-ray 2.85A ) 4U7Z (X-ray 2.80A ) 4U80 (X-ray 2.80A ) 4U81 (X-ray 2.70A ) 5BX0 (X-ray 2.93A ) 5EYM (X-ray 2.70A ) 5HZE (X-ray 2.40A ) 5YT3 (X-ray 2.90A ) 6NYB (EM 4.10A ) 6PP9 (X-ray 2.59A ) 6Q0J (EM 4.90A ) 6Q0T (EM 5.70A ) 6U2G (X-ray 2.89A ) 6V2W (X-ray 3.12A ) 6X2P (X-ray 2.40A ) 6X2S (X-ray 2.50A ) 6X2X (X-ray 2.46A ) 7B3M (X-ray 2.30A ) 7B7R (X-ray 1.70A ) 7B94 (X-ray 2.00A ) 7B9L (X-ray 1.70A ) 7M0T (X-ray 3.19A ) 7M0U (X-ray 3.09A ) 7M0V (X-ray 3.16A ) 7M0W (X-ray 3.09A ) 7M0X (X-ray 2.47A ) 7M0Y (X-ray 3.45A ) 7M0Z (X-ray 3.12A ) 7MFD (EM 3.66A ) 7PQV (X-ray 2.13A ) |
| DBSNP | rs121908594 rs1057519729 rs397516790 rs869025608 rs121908596 rs121908595 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14737111}. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body {ECO:0000269|PubMed:14737111}. Cytoplasm {ECO:0000269|PubMed:10409742, ECO:0000269|PubMed:17101779}. Nucleus {ECO:0000269|PubMed:17101779}. Membrane {ECO:0000269|PubMed:10409742}; Peripheral membrane protein {ECO:0000269|PubMed:10409742}. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). {ECO:0000269|PubMed:10409742, ECO:0000269|PubMed:14737111}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |