| Gene Information | |
|---|---|
| Gene Name | MEST |
| Organism | Homo sapiens (Human) |
| Gene Length | 335 |
| Protein Names | Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000106484 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q5EB52 |
| Gene Card | MEST |
| Uniprot ID | Q5EB52 |
| Pfam | PF00561 |
| In ASD | no |
| Allosteric Prediction | no (-0.603587468) |
| Ortholog in Animals | Alpaca_ MEST ( ortholog_one2one ) Dog_ MEST ( ortholog_one2many ) GuineaPig_ MEST ( ortholog_one2one ) Macaque_ MEST ( ortholog_one2many ) Mouse_ Mest ( ortholog_one2one ) Pig_ MEST ( ortholog_one2one ) Rat_ Mest ( ortholog_one2one ) Rabbit_ MEST ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SERHL2, EPHX4, ABHD6, ABHD8, ABHD11, EPHX2, ABHD5, ABHD4, ABHD14B, BPHL, ABHD14A, EPHX3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele. {ECO:0000269|PubMed:8884280, ECO:0000269|PubMed:9192843}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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