| Gene Information | |
|---|---|
| Gene Name | MIA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1907 |
| Protein Names | Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000154305 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5JRA6 |
| Gene Card | MIA3 |
| Uniprot ID | Q5JRA6 |
| Pfam | PF07653 |
| In ASD | no |
| Allosteric Prediction | no (-0.571997879) |
| Ortholog in Animals | Alpaca_ MIA3 ( ortholog_one2one ) Dog_ MIA3 ( ortholog_one2one ) GuineaPig_ MIA3 ( ortholog_one2one ) Macaque_ MIA3 ( ortholog_one2one ) Mouse_ Mia3 ( ortholog_one2one ) Pig_ MIA3 ( ortholog_one2one ) Rat_ Mia3 ( ortholog_one2one ) Rabbit_ MIA3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPZ1, CTAGE1, CTAGE8, CTAGE9, CTAGE6, MIA2, CTAGE4, CTAGE15, MIA, OTOR |
| Tissue | NA |
| Tissue Specificity | Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue. {ECO:0000269|PubMed:15183315, ECO:0000269|PubMed:17044017}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5KYN (X-ray 2.55A ) 5KYU (X-ray 3.51A ) 5KYW (X-ray 3.20A ) |
| DBSNP | rs2936053 rs2936052 rs2936051 rs17857325 rs17854428 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:32101163}; Single-pass membrane protein {ECO:0000269|PubMed:19269366}. Note=Localizes at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:32101163). SEC16A is required for its proper localization to ERES. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane. {ECO:0000269|PubMed:19269366, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:28442536}. |
| Mouse PG classification | NA |
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