| Gene Information | |
|---|---|
| Gene Name | ARHGEF18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1361 |
| Protein Names | Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000104880 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q6ZSZ5 |
| Gene Card | ARHGEF18 |
| Uniprot ID | Q6ZSZ5 |
| Pfam | PF17838; PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-0.188269401) |
| Ortholog in Animals | Dog_ ARHGEF18 ( ortholog_one2one ) Macaque_ ARHGEF18 ( ortholog_one2one ) Mouse_ Arhgef18 ( ortholog_one2one ) Pig_ ARHGEF18 ( ortholog_one2one ) Rat_ Arhgef18 ( ortholog_one2one ) |
| Ohnologs | ARHGEF2 |
| Paralogs | ARHGEF28, ARHGEF12, NET1, ARHGEF11, PLEKHG6, ARHGEF3, ARHGEF1, ARHGEF2 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils (PubMed:29601110). Isoform 2: Expressed in eosinophils (PubMed:29601110). Isoform 3: Expressed in eosinophils (PubMed:29601110). Isoform 4: Not detected in eosinophils (PubMed:29601110). {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029, ECO:0000269|PubMed:29601110}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs987233144 rs2287918 rs2287920 rs9329368 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15558029}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15558029}. Cell membrane {ECO:0000269|PubMed:29601110}. Apical cell membrane {ECO:0000269|PubMed:22006950}. Note=In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (PubMed:29601110). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (PubMed:29601110). Localizes to the apical cell membrane in epithelial cells (PubMed:22006950). {ECO:0000269|PubMed:22006950, ECO:0000269|PubMed:29601110}. |
| Mouse PG classification | NA |
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