| Gene Information | |
|---|---|
| Gene Name | ARHGEF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 912 |
| Protein Names | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000076928 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q92888 |
| Gene Card | ARHGEF1 |
| Uniprot ID | Q92888 |
| Pfam | PF17838; PF09128; PF00621 |
| In ASD | no |
| Allosteric Prediction | yes (0.270090644) |
| Ortholog in Animals | Alpaca_ ARHGEF1 ( ortholog_one2one ) Dog_ ARHGEF1 ( ortholog_one2one ) Macaque_ ARHGEF1 ( ortholog_one2one ) Mouse_ Arhgef1 ( ortholog_one2one ) Pig_ ARHGEF1 ( ortholog_one2one ) Rat_ Arhgef1 ( ortholog_one2one ) |
| Ohnologs | ARHGEF12 |
| Paralogs | ARHGEF28, ARHGEF12, ARHGEF18, NET1, ARHGEF11, PLEKHG6, ARHGEF3, ARHGEF2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:8810315, ECO:0000269|PubMed:9135076}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1IAP (X-ray 1.90A ) 1SHZ (X-ray 2.85A ) 3AB3 (X-ray 2.40A ) 3ODO (X-ray 2.90A ) 3ODW (X-ray 3.20A ) 3ODX (X-ray 3.20A ) 3P6A (X-ray 2.50A ) |
| DBSNP | rs1568815169 rs2303797 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10747909}. Membrane {ECO:0000269|PubMed:10747909}. Note=Translocated to the membrane by activated GNA13 or LPA stimulation. |
| Mouse PG classification | NA |
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