| Gene Information | |
|---|---|
| Gene Name | PXK |
| Organism | Homo sapiens (Human) |
| Gene Length | 578 |
| Protein Names | PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000168297 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z7A4 |
| Gene Card | PXK |
| Uniprot ID | Q7Z7A4 |
| Pfam | PF00787; PF02205 |
| In ASD | no |
| Allosteric Prediction | no (-0.079198862) |
| Ortholog in Animals | Alpaca_ PXK ( ortholog_one2one ) Dog_ PXK ( ortholog_one2one ) GuineaPig_ PXK ( ortholog_one2one ) Macaque_ PXK ( ortholog_one2one ) Mouse_ Pxk ( ortholog_one2one ) Pig_ PXK ( ortholog_one2one ) Rat_ Pxk ( ortholog_one2one ) Rabbit_ PXK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SNX16 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated. {ECO:0000269|PubMed:16142408}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs55973253 rs56384862 rs34579268 rs34579268 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16142408}. Cell membrane {ECO:0000269|PubMed:16142408}; Peripheral membrane protein {ECO:0000269|PubMed:16142408}. Note=Also associates with the plasma membrane. Isoform 3 is present throughout the cell. |
| Mouse PG classification | NA |
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