| Gene Information | |
|---|---|
| Gene Name | ARHGAP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 946 |
| Protein Names | Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000089820 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P98171 |
| Gene Card | ARHGAP4 |
| Uniprot ID | P98171 |
| Pfam | PF00611; PF00620; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.27314313) |
| Ortholog in Animals | Alpaca_ ARHGAP4 ( ortholog_one2one ) Dog_ ARHGAP4 ( ortholog_one2one ) Macaque_ ARHGAP4 ( ortholog_one2one ) Mouse_ Arhgap4 ( ortholog_one2one ) Pig_ ARHGAP4 ( ortholog_one2one ) Rat_ Arhgap4 ( ortholog_one2one ) Rabbit_ ARHGAP4 ( ortholog_one2one ) |
| Ohnologs | SRGAP3, SRGAP1 |
| Paralogs | SRGAP3, SRGAP1, SRGAP2B, SRGAP2, SRGAP2C |
| Tissue | NA |
| Tissue Specificity | Predominantly in hematopoietic cells (spleen, thymus and leukocytes); low levels in placenta, lung and various fetal tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EPD (NMR - ) |
| DBSNP | rs5987182 |
| Subcellular location [CC] | Cytoplasm. Note=Just below the plasma membrane. |
| Mouse PG classification | NA |
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