| Gene Information | |
|---|---|
| Gene Name | ARHGAP27 |
| Organism | Homo sapiens (Human) |
| Gene Length | 889 |
| Protein Names | Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000159314 ) 3 ( ENSG00000276836 ) 3 ( ENSG00000276907 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6ZUM4 |
| Gene Card | ARHGAP27 |
| Uniprot ID | Q6ZUM4 |
| Pfam | PF00169; PF00620; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.524131153) |
| Ortholog in Animals | Alpaca_ ARHGAP27 ( ortholog_one2one ) GuineaPig_ ARHGAP27 ( ortholog_one2one ) Macaque_ ARHGAP27 ( ortholog_one2one ) Mouse_ Arhgap27 ( ortholog_one2one ) Pig_ ARHGAP27 ( ortholog_one2one ) Rat_ Arhgap27 ( ortholog_one2one ) Rabbit_ ARHGAP27 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARHGAP12, ARHGAP9, ARHGAP15 |
| Tissue | NA |
| Tissue Specificity | Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer. {ECO:0000269|PubMed:15492870}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3PP2 (X-ray 1.42A ) |
| DBSNP | rs117139057 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |