| Gene Information | |
|---|---|
| Gene Name | ARHGAP24 |
| Organism | Homo sapiens (Human) |
| Gene Length | 748 |
| Protein Names | Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000138639 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N264 |
| Gene Card | ARHGAP24 |
| Uniprot ID | Q8N264 |
| Pfam | PF00169; PF00620 |
| In ASD | no |
| Allosteric Prediction | no (-0.400365177) |
| Ortholog in Animals | Alpaca_ ARHGAP24 ( ortholog_one2one ) Dog_ ARHGAP24 ( ortholog_one2one ) GuineaPig_ ARHGAP24 ( ortholog_one2one ) Macaque_ ARHGAP24 ( ortholog_one2one ) Mouse_ Arhgap24 ( ortholog_one2one ) Pig_ ARHGAP24 ( ortholog_one2one ) Rat_ Arhgap24 ( ortholog_one2one ) Rabbit_ ARHGAP24 ( ortholog_one2one ) |
| Ohnologs | ARHGAP22, ARHGAP25 |
| Paralogs | ARHGAP25, ARHGAP22 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions. |
| Mouse PG classification | NA |
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