| Gene Information | |
|---|---|
| Gene Name | ARHGAP21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1958 |
| Protein Names | Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000107863 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q5T5U3 |
| Gene Card | ARHGAP21 |
| Uniprot ID | Q5T5U3 |
| Pfam | PF17820; PF00169; PF00620 |
| In ASD | no |
| Allosteric Prediction | no (-0.895465535) |
| Ortholog in Animals | Alpaca_ ARHGAP21 ( ortholog_one2one ) Dog_ ARHGAP21 ( ortholog_one2one ) GuineaPig_ ARHGAP21 ( ortholog_one2one ) Macaque_ ARHGAP21 ( ortholog_one2one ) Mouse_ Arhgap21 ( ortholog_one2one ) Pig_ ARHGAP21 ( ortholog_one2one ) Rat_ Arhgap21 ( ortholog_one2one ) Rabbit_ ARHGAP21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARHGAP23 |
| Tissue | cerebellum |
| Tissue Specificity | Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. {ECO:0000269|PubMed:12056806}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DHJ (NMR - ) 2J59 (X-ray 2.10A ) 2YUY (NMR - ) |
| DBSNP | rs3748222 rs1133897 rs1143051 rs1143057 rs1143075 rs1127893 |
| Subcellular location [CC] | Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. |
| Mouse PG classification | NA |
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