Gene Information
Gene NameSTK26
OrganismHomo sapiens (Human)
Gene Length416
Protein NamesSerine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK)
Target Nameserine/threonine-protein kinase mst4
Target TypeNA
Gene Age544 ( ENSG00000134602 )
Evolutionary StageEukaryota
AlphaFoldDBQ9P289
Gene CardSTK26
Uniprot IDQ9P289
PfamPF00069
In ASDno
Allosteric Predictionyes (0.079591675)
Ortholog in AnimalsAlpaca_ STK26 ( ortholog_one2one )
Alpaca_ STK26 ( ortholog_one2many )
Dog_ STK26 ( ortholog_one2one )
GuineaPig_ STK26 ( ortholog_one2one )
Macaque_ STK26 ( ortholog_one2one )
Mouse_ Stk26 ( ortholog_one2one )
Pig_ STK26 ( ortholog_one2one )
Rabbit_ STK26 ( ortholog_one2one )
OhnologsSTK24, STK25
ParalogsPAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3GGF  (X-ray  2.35A  )  3W8I  (X-ray  2.40A  )  4FZA  (X-ray  3.15A  )  4FZD  (X-ray  3.25A  )  4FZF  (X-ray  3.64A  )  4GEH  (X-ray  1.95A  )  5XY9  (X-ray  2.30A  )  5YF4  (X-ray  1.90A  )  7B36  (X-ray  2.11A  ) 
DBSNP rs56035648  rs56044451 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:27807006}. Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000269|PubMed:27807006}.
Mouse PG classificationNA
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