| Gene Information | |
|---|---|
| Gene Name | ARHGAP10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 786 |
| Protein Names | Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000071205 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | A1A4S6 |
| Gene Card | ARHGAP10 |
| Uniprot ID | A1A4S6 |
| Pfam | PF00169; PF00620; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.999961743) |
| Ortholog in Animals | Alpaca_ ARHGAP10 ( ortholog_one2one ) Dog_ ARHGAP10 ( ortholog_one2one ) GuineaPig_ ARHGAP10 ( ortholog_one2one ) Macaque_ ARHGAP10 ( ortholog_one2one ) Mouse_ Arhgap10 ( ortholog_one2one ) Pig_ ARHGAP10 ( ortholog_one2one ) Rat_ Arhgap10 ( ortholog_one2one ) Rabbit_ ARHGAP10 ( ortholog_one2one ) |
| Ohnologs | OPHN1, ARHGAP26, ARHGAP42 |
| Paralogs | OPHN1, ARHGAP42, ARHGAP26 |
| Tissue | NA |
| Tissue Specificity | High levels of expression in heart and skeletal muscle. {ECO:0000269|PubMed:11432776}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MIO (NMR - ) |
| DBSNP | rs17024215 rs2276932 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}. |
| Mouse PG classification | NA |
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