| Gene Information | |
|---|---|
| Gene Name | ARFGEP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1849 |
| Protein Names | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y6D6 |
| Gene Card | ARFGEF1 |
| Uniprot ID | Q9Y6D6 |
| Pfam | PF20252; PF16213; PF09324; PF01369; PF12783 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, lung, heart, brain, kidney and pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3LTL (X-ray 2.20A ) 5EE5 (X-ray 2.28A ) 5J5C (X-ray 3.40A ) |
| DBSNP | rs4321984 |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000269|PubMed:12571360}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27373159, ECO:0000269|PubMed:27436755}. Nucleus {ECO:0000269|PubMed:14973189}. Nucleus, nucleolus {ECO:0000269|PubMed:14973189}. Nucleus matrix {ECO:0000269|PubMed:14973189}. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment. |
| Mouse PG classification | NA |
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